Tozkoparan, BirsenAytac, Sevim PeriAktay, Goeknur2024-08-042024-08-0420090365-6233https://doi.org/10.1002/ardp.200800188https://hdl.handle.net/11616/94806In this study, the synthesis of a new series of 3,6-disubstituted-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine 1a-4c Compounds derived from 4-amino-3-substituted-1,2,4-triazole-5-thiones 1-4 is described. All of the synthesized compounds were screened for their possible analgesic / anti-inflammatory, antioxidant activities and gastric toxicity. The compound 2c was found to have both significant analgesic and consistent anti-inflammatory activity without inducing any gastric lesions along with minimal lipid peroxidation. A deep insight into the structures of the active compounds revealed that the compounds carrying an electron withdrawing group (a chloride or fluoride) on the phenyl ring at 6-position of the condensed heterocyclic derivatives exhibited noticeable higher activity.eninfo:eu-repo/semantics/closedAccess4-Amino-3-mercapto-1,2,4-triazoleAnalgesic activityAnti-inflammatory activityAntioxidant activity1,2,4-Triazolo[3,4-b][1,3,4]thiadiazinesArticle34252912981941566010.1002/ardp.2008001882-s2.0-66349108764N/AWOS:000266509000004Q2