Karaca, Emine OzgeCiftci, OsmanOzdemir, IlknurYakali, GulAygun, MuhittinGurbuz, NevinOzdemir, Ismail2024-08-042024-08-0420190268-26051099-0739https://doi.org/10.1002/aoc.4851https://hdl.handle.net/11616/98783Platinum (II) complexes bearing N-heterocyclic carbene (NHC) ligands have been widely used in catalytic chemistry, but there are very few reports of biological properties of this type of complexes. A series of [PtCl2(NHC)(PEt3)] complexes were synthesized. The structures of all compounds were characterized by H-1-NMR, C-13-NMR, IR and elemental analysis techniques, which supported the proposed structures. The single crystal structures of complexes 1a and 1e were determined. The title complexes show slightly distorted square-planar coordination around the platinum (II) metal center. The cytotoxic properties of the platinum (II)-NHC complexes have been assessed in various human cancer lines, including cisplatin-sensitive and resistant cells. IC50 values of these four complexes were determined by the MTS-based assay on three human cell lines-brain (SHSY5Y), colon (HTC116) and liver (HEP3B). These complexes have been highlighted cancer therapeutic agent with unique structures and functions.eninfo:eu-repo/semantics/closedAccessantitumor activityImidazolidine-2-ylideneN-heterocyclic carbeneplatinum complexesArticle33710.1002/aoc.48512-s2.0-85065401538Q2WOS:000475943500035Q1