Jawhari, Ahmed HussainAmri, NasserMukhrish, Yousef E.Gatri, RafikOzdemir, IsmailGurbuz, NevinMansour, Lamjed2024-08-042024-08-0420230792-12412191-0219https://doi.org/10.1515/mgmc-2023-0008https://hdl.handle.net/11616/101707A series of ruthenium(ii) complexes with N-heterocyclic carbene (NHC) ligands of the general type (arene)(NHC)Ru(ii)X-2 (where X = halide) (3a-3d) were synthesized and characterized in order to compare their antibacterial activities with benzimidazolium salts 2. Our comparison revealed that ruthenium(ii) NHC complexes 3 were more active than benzimidazolium salts 2. Furthermore, the two complexes 3b and 3d had a potent inhibitory effect against acetylcholinesterase with an IC50 of 4.52 and 4.04 gmL(-1) and against tyrosinase with an IC50 of 20.77 and 25.84 gmL(-1), respectively. In addition, screening of benzimidazolium salts (2a-2d) and their ruthenium(ii) complexes (3a-3d) against colon carcinoma cell lines (HCT-116) and hepatocellular carcinoma cell lines (HepG-2) were studied. The obtained results revealed that complex 3a is the most active against vinblastines.eninfo:eu-repo/semantics/openAccessbiological activitybenzimidazolium saltsruthenium complexessilver complexesHCT-116HepG-2Article46110.1515/mgmc-2023-00082-s2.0-85179054459Q3WOS:001109537000001Q3