Goekhan-Kelekci, NesrinKoeksal, MericUenuevar, SonguelAktay, GoeknurErdogan, Hakki2024-08-042024-08-0420091475-6366https://doi.org/10.1080/14756360701841772https://hdl.handle.net/11616/94741The synthesis, characterization and pharmacological activities of a new series of (6-difluorobenzoyl)-5-methyl-3-benzoylmethyl-2(3H)-benzoxazolone and 5-methyl-3-(2-hydroxyl-2-phenylethyl)-2(3H)-benzoxazolone are described. Antiinflammatory activity was investigated by the carrageenin-induced paw oedema test and analgesic activity by acetic acid writhing and hot plate tests in mice. Among the synthesized compounds, compound 3e 6-(2,5-difluorobenzoyl)-3-(4-bromobenzoylmethyl-2(3H)-benzoxazolone was found to be the most promising compound for analgesic activity. Reduced compounds (4a-4d) displayed considerable anti-inflammatory activity compared to the other derivatives.eninfo:eu-repo/semantics/closedAccess2(3H)-Benzoxazoloneanalgesic-antiinflammatory activitiesArticle24129371912748110.1080/147563607018417722-s2.0-58949085635N/AWOS:000262718700005Q3