Togal T.Demirbilek S.Gulhas N.Koroglu A.2024-08-042024-08-0420040169-1112https://doi.org/10.1163/1568569041798308https://hdl.handle.net/11616/90522The aim of this double-blind prospective randomized study was to investigate combination of low-dose (0.1 mg) intrathecal morphine and patient-controlled intravenous morphine in the management of postoperative pain following abdominal hysterectomy. Side-effects, satisfaction and sedation were also evaluated. Fifty patients (ASA I) between 30 and 65 years of age, scheduled for elective abdominal hysterectomy were randomized to receive intrathecal 0.1 mg of morphine sulfate (ITM) or placebo and intravenous morphine (IVM). Both groups received standard general anesthesia. In the ITM group, 0.1 mg morphine was administered intrathecally just before emergence from anesthesia while an equal volume of sterile saline was administered in the IVM group. Thereafter, all patients received IV morphine via a patient controlled analgesia (PCA) pump, set to deliver a bolus of 1 mg with a lock-out of 7 minutes and maximum dose of 20 mg per 4 hours. Hemodynamics, respiration, PCA demands, VAS, sedation scores, total morphine consumption, satisfaction and side effects were recorded for 24 hours after surgery. There were no significant differences between the groups with respect to satisfaction score. Total morphine consumption was lower in the ITM group; VAS scores at the first 8 hours were lower in the ITM group. Sedation scores at 4, 8, and 12th hours were higher in the ITM group. There was no significant difference in terms of adverse effects. In conclusion, intrathecal morphine (0.1 mg) combined with intravenous PCA is a safe and effective method of providing analgesia after hysterectomy as evidenced by lower pain scores and total morphine consumption and improved patient satisfaction.eninfo:eu-repo/semantics/closedAccessAnalgesiaIntrathecalMorphinePostoperativeArticle16333534110.1163/15685690417983082-s2.0-4744353726N/A