Gulubova, MayaTolekova, AnnaBerbatov, DimitarAydogdu, Nurettin2024-08-042024-08-0420231381-34551744-4160https://doi.org/10.1080/13813455.2023.2252205https://hdl.handle.net/11616/101552ContextThere is data about the existence of some endocrine cells in the epithelial layer of the bile duct in humans and rats.ObjectiveWe evaluated Ghrelin-, Insulin-, Glucagon- and Somatostatin-positive cells in peribiliary glands, mast cells, and nerve fibres.Materials and methodsWistar rats were used for dietary manipulation with a 15% fructose solution for 12 weeks. Tissue samples were elaborated with immunohistochemistry for Insulin, Glucagon, Ghrelin, and Somatostatin. Glucose and lipid parameters were studied.ResultsIn treated animals, Ghrelin+ and Insulin+ cells in perybiliary glands (PBGs) were significantly increased. In the male fructose group there was a significant increase of the homeostasis model assessment insulin resistance (HOMA-IR).ConclusionsStem/progenitor cells in extrahepatic bile tree (EHBT) could be a source of Insulin-producing cells in metabolic syndrome. Fructose treatment induces the increase of Ghrelin+ and Insulin+ cells in PBGs and the elevation of Insulin and Ghrelin plasma concentration.eninfo:eu-repo/semantics/closedAccessGhrelininsulinglucagonsomatostatinperibiliary glandsArticle3765158610.1080/13813455.2023.22522052-s2.0-85169313003Q2WOS:001062443000001Q2