Cizmeci, ZeynepAktas, ElifOtlu, BarisAcikgoz, OzlemOrdekci, Seyhan2024-08-042024-08-0420171120-009X1973-9478https://doi.org/10.1080/1120009X.2017.1323149https://hdl.handle.net/11616/97813We aimed to characterize carbapenem-resistant isolates in a tertiary hospital in Istanbul, Turkey, high-prevelance area for OXA-48 producers. About 76 Enterobacteriaceae clinical isolates were included. Carbapenemase production was detected by Carbapenem Inactivation Method and carbapenemase genes were investigated by PCR. The clonal relationships were evaluated by AP-PCR. Nineteen Klebsiella pneumoniae isolates were colistin resistant. About 75 isolates yielded carbapenemase by CIM. 52 OXA-48, 17 NDM-1 and 2 VIM-5 carbapenemase genes were detected. Co-production of 'OXA-48 and NDM-1' and 'OXA-48 and VIM-5' were demonstrated in two Klebsiella pneumoniae isolates. The total clustering rate was 20.2%. About 69 Klebsiella pneumoniae yielded 60 profiles and 12 isolates formed five clusters. We have demonstrated the presence of OXA-48 carbapenemases in the majority of isolates in a large collection of carbapenemase-producing isolates from a single hospital. The relatively high rates of NDM-1-producing isolates and colistin resistance is noteworthy.eninfo:eu-repo/semantics/closedAccessEnterobacteriaceaeCarbapenemasesMolecular characterizationOXA-48NDM-1Colistin resistanceArticle2963443502848684010.1080/1120009X.2017.13231492-s2.0-85019135186Q3WOS:000423162200003Q4