Boubakri, LamiaAl-Ayed, Abdullah S.Mansour, L.Abutaha, NaelHarrath, Abdel HalimOzdemir, IYasar, S.2024-08-042024-08-0420190095-89721029-0389https://doi.org/10.1080/00958972.2019.1664738https://hdl.handle.net/11616/99001Pd(II)-bis(NHC) complexes (where NHC = N-heterocyclic carbene) bearing asymmetrically and symmetrically substituted NHC-ligand have been synthesized via deprotonation of 5,6-dimethylbenzimidazolium salts. The NHC precursors have been achieved via the two step N-alkylation of 5,6-dimethylbenzimidazole. The resultant salts were deprotonated with PdCl2 and K2CO3 in dry THF for 2(a-e). The obtained complexes were identified and characterized by H-1 and C-13 NMR, FT-IR, DART-TOF mass spectrometry and elemental analysis. These new Pd(II)-bis(NHC) complexes were applied as catalyst precursors for Suzuki-Miyaura cross-coupling reactions of aryl bromides and chlorides with phenylboronic acid to afford the corresponding products in good yields. This catalytic reaction was evaluated in the presence of KOtBu/toluene. The antibacterial activities of 2(a-e) were investigated against Gram (+)/(-) bacteria using the agar dilution procedure. The antibacterial activities of 2 vary with the nature of the ligands; MIC values of 2(a-e) were determined.eninfo:eu-repo/semantics/closedAccessSuzuki-Miyaura couplingN-heterocyclic carbenePd(II)-bis(NHC) catalystantibacterial activityArticle72162688270410.1080/00958972.2019.16647382-s2.0-85074052782Q3WOS:000487442600001Q3