Hacioglu, SibelBilen, YusufEser, AliSivgin, SerdarGurkan, EmelYildirim, RahsanAydogdu, Ismet2024-08-042024-08-0420150278-02321099-1069https://doi.org/10.1002/hon.2177https://hdl.handle.net/11616/97130In this multicenter retrospective analysis, we aimed to present clinical, laboratory and treatment results of 94 patients with Hairy cell leukemia diagnosed in 13 centers between 1990 and 2014. Sixty-six of the patients were males and 28 were females, with a median age of 55. Splenomegaly was present in 93.5% of cases at diagnosis. The laboratory findings that came into prominence were pancytopenia with grade 3 bone marrow fibrosis. Most of the patients with an indication for treatment were treated with cladribine as first-line treatment. Total and complete response of cladribine was 97.3% and 80.7%. The relapse rate after cladribine was 16.6%, and treatment related mortality was 2.5%. Most preferred therapy ( 95%) was again cladribine at second-line, and third line with CR rate of 68.4% and 66.6%, respectively. The 28-month median OS was 91.7% in all patients and 25-month median OS 96% for patients who were given cladribine as first-line therapy. In conclusion, the first multicenter retrospective Turkish study where patients with HCL were followed up for a long period has revealed demographic characteristics of patients with HCL, and confirmed that cladribine treatment might be safe and effective in a relatively large series of the Turkish study population. Copyright (C) 2014 John Wiley & Sons, Ltd.eninfo:eu-repo/semantics/closedAccesshairy cell leukemiaTurkeytreatmentcladribinsurvivalArticle3341921982539384710.1002/hon.21772-s2.0-84954543319Q1WOS:000368248400011Q2