Yilmaz, ErcanGul, MehmetMelekoglu, RaufKoleli, Isil2024-08-042024-08-0420180102-86501678-2674https://doi.org/10.1590/s0102-865020180070000009https://hdl.handle.net/11616/98433Purpose: To investigate the place of the transcription factor nuclear kappa B (NF-kappa B), which is a marker of chronic inflammation, in the etiology of the ovarian carcinoma. Methods: NFkB analysis with the immunohistochemical method has been performed. To evaluate immunohistochemical NF-kappa B expression in the ovarian tissue, the H-score method. H-score = Sigma Pi (i+1), where Pi'' is the percentage of stained cells in each intensity category (0-100%) and i'' is the intensity indicating weak (i=1), moderate (i=2) or strong staining (i=3). Results: It has been seen that, the mean H score is statistically significantly higher in the patient group with serous and musinous adenocarcinoma diagnosis than the two other patient groups (p<0.005). Conclusions: Factor nuclear kappa B is an important mediator that acts in the chronic inflammation. The highest expression rates are determined by the immunohistochemical method in the ovarian cancer group.eninfo:eu-repo/semantics/openAccessNF-kappa BOvarianNeoplasmsInflammationEtiologyArticle3376416503011006510.1590/s0102-8650201800700000092-s2.0-85051722790Q3WOS:000441179000009Q4