Akkoc, SenemKayser, VeyselIlhan, Ilhan OzerHibbs, David E.Gok, YetkinWilliams, Peter A.Hawkins, Bryson2024-08-042024-08-0420170022-328X1872-8561https://doi.org/10.1016/j.jorganchem.2017.03.037https://hdl.handle.net/11616/97783Benzimidazolium salts and their Pyridine Enhanced Precatalyst Preparation Stabilization and Initiation (PEPPSI) palladium N-heterocyclic carbene (Pd-NHC) based complexes have been synthesized and their structures characterized with a number of different instrumental techniques including NMR (H-1 and C-13), IR, EI-MS (for 2), X-ray (for 1, 2 and 4) and elemental analysis. The cytotoxicity of all the compounds was tested using the human embryonic kidney (HEK-293T), human breast epithelial adenocarcinoma (MDA-MB-231), and human colon epithelial colorectal adenocarcinoma (DLD-1) cell lines. The benzimidazolium salts (2-5) had more cytotoxic activity against cancerous cells compared with the metal complexes (6-9), which curiously exhibited no activity against any of the cell lines. Based on the IC50 values, compound 5 displayed the highest in vitro anticancer activity among compounds 2-9. Crown Copyright (C) 2017 Published by Elsevier B.V. All rights reserved.eninfo:eu-repo/semantics/closedAccessN-Heterocyclic carbenePEPPSIBenzimidazolium saltsCytotoxic activityX-rayConfocal and incucyte imagesArticle8399810710.1016/j.jorganchem.2017.03.0372-s2.0-85017569714Q3WOS:000401126300014Q2