Karlik, OzgulGencer, NahitKaratas, Mert O.Ergun, AdemCikrikci, KubraArslan, OktayAlici, Bulent2024-08-042024-08-0420190365-62331521-4184https://doi.org/10.1002/ardp.201800325https://hdl.handle.net/11616/98600A series of 1-substituted-1H-benzimidazolium p-toluenesulfonate salts were synthesized in good yields by the reaction of 1-substituted benzimidazole derivatives and p-toluenesulfonic acid under microwave irradiation. Two iodide salts were synthesized by the anion exchange reaction of the corresponding p-toluenesulfonate salt and NaI. All compounds were characterized by H-1 NMR, C-13 NMR, IR, LC-MS spectroscopic methods, and elemental analyses. The crystal structure of 1-methoxyethyl-1H-benzimidazolium p-toluenesulfonate 2d showed that cation and anion are interconnected by N-H center dot center dot center dot O and C-H center dot center dot center dot O hydrogen bonds. All compounds were examined as inhibitor of human carbonic anhydrase (hCA) I and II, and all of them inhibited hCA I and hCA II. Kinetic investigation results revealed that these compounds inhibit hCA I and hCA II in a non-competitive manner. The iodide salts had higher inhibitory activity than their corresponding p-toluenesulfonate salts.eninfo:eu-repo/semantics/closedAccessbenzimidazolebenzimidazolium saltcarbonic anhydraseinhibitorsmicrowave chemistryArticle35243061455810.1002/ardp.2018003252-s2.0-85059605127Q2WOS:000462879700003Q2