Gülhaş N.Türköz A.Bayramlar H.Durmuş M.Gedik E.Da?lio?lu M.C.Ersoy M.Ö.2024-08-042024-08-0420011016-5150https://hdl.handle.net/11616/90844We aimed to investigate the effect of oral clonidine on postoperatory nausea and vomiting (PONV) in forty patients who underwent strabismus surgery. Patients were divided into two groups in this randomized and double blind prospective study. In Group I (n=20), patients were orally administered 4 ?g/kg clonidine within 0.2 mL/kg apple juice one hour before surgery. Group II, the control Group, were given only apple juice in same volume. Anesthesia was induced by atropine 0.02 mg/kg, lidocaine 2 mg/kg, propofol 3 mg/kg and vecuronium 0.1 mg/kg. Sevoflurane 2 % and N20 60 % in oxygen 40 % was used for maintenance The nausea and vomiting episodes were scored from 0 to 3 as follows: score 0: no nausea-vomiting; score 1: only nausea; score 2: some nausea-vomiting not needed treatment; score 3: severe vomiting needing treatment (metoclopramide 0.15 mg/kg). Nausea and vomiting was observed in five children in Group I (25 %) and in 8 children in Group II (40 %) (p<0.05) in first 6 hours of postoperative period. During first 48 hours, the rate of nausea and vomiting increased to 8 (40 %) and 12 (60 %) children in Group I and II, respectively (p<0.05). There was no statistically significant difference between two groups at other intervals. In conclusion clonidine which is given orally preoperatively reduced the rate of PONV in children who underwent strabismus surgery.trinfo:eu-repo/semantics/closedAccessClonidinePostoperative nausea and vomitingStrabismus surgeryArticle2952022052-s2.0-0034932778N/A