Bayındır, TubaToplu, YükselOtlu, BarışYakupoğulları, YusufYıldırım, ÖzgeKalcıoğlu, Mahmut Tayyar2017-07-102017-07-102015Bayındır, T. Toplu, Y. Otlu, B. Yakupoğulları, Y. Yıldırım, Ö. Kalcıoğlu, M. T. (2015). Prevalence of the Helicobacter pylori in the tonsils and adenoids. Brazilian Journal of Otorhinolaryngology, 81(3), 307–311.18088694http://linkinghub.elsevier.com/retrieve/pii/S1808869415000440https://hdl.handle.net/11616/7355Introduction: There is an ongoing debate about the existence and effects of Helicobacter pylori (Hp) in adenotonsillar tissue. Objective: A clinical study was conducted to assess the existence of Hp in the adenoid and/or adenotonsillar tissues, which were surgically excised due to chronic adenotonsillitis. Methods: Phosphoglucosamine mutase gene for the detection of Hp and cytotoxin-associated gene as virulence gene were examined in 84 adenotonsillar tissues obtained from 64 patients and patients’ serum by using polymerase chain reaction. Results: Hp IgG was detected in 57 (89%) patients’ serum. A total of seven tissue samples from 64 patients (10.9%) were found positive for Hp DNA, of which five were adenoids and two were tonsil tissues. All polymerase chain reaction positive samples were also positive for the cytotoxin-associated gene, which is a virulence determinant for the organism. Conclusion: This study suggests that children are exposed to Hp at an early age of their life in this province. Hp may have a role in the pathogenesis of chronic adenotonsillitis, especially in endemic areas. © 2015 Associac¸ão Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.eninfo:eu-repo/semantics/openAccessHelicobacter pyloriReservoirsAdenoidsPalatine tonsilArticle81330731110.1016/j.bjorl.2014.08.018