Ünver, ZeynepCengiz, Zeliha2026-04-042026-04-0420252602-3741https://doi.org/10.54005/geneltip.1636308https://search.trdizin.gov.tr/tr/yayin/detay/1337830https://hdl.handle.net/11616/108229Aim: To determine whether frailty and cognitive impairment affect rational use of medicines in older individuals. Methods: The descriptive cross-sectional study was conducted in eastern Turkey. A total of 251 older individuals aged 60 years were included. In addition to demographic and medical characteristics, frailty status, mental status, and rational use of medicines were measured in a 25-35 minute scale administration period. Results: The frailty scores of the participants were 1.65±1.22, rational use of medicines scores were 72.16±16.31, and mental status scores were 20.83±5.46. Rational use of medicines had a statistically significant negative correlation with frailty (r=-,314) and a statistically significant positive correlation with mental status (r=,595**). There was a statistically significant difference in rational use of medicines according to polypharmacy, history of hospitalization, educational status, income, age, and cohabitant variables (p<0.05). Regression analysis showed that the final model of rational use of medicines including mental status score, income, educational status, age, and cohabitant variables explained 43% of the total variance. Conclusions: Rational use of medicines was adequate in the elderly, but cognitive impairment and frailty negatively affected rational use of medicines. Accordingly, it is recommended that mental status and frailty factors should be taken into consideration to ensure that the use of medicines in older individuals is in accordance with the principles of rational use of medicines. © 2025, Selcuk University. All rights reserved.eninfo:eu-repo/semantics/openAccessCognitive impairmentfrailtymental statusolder adultsrational use of medicinesArticle35461362310.54005/geneltip.16363082-s2.0-105016849841N/A1337830