Guler, CigdemToy, EbubekirOzturk, FiratGunes, DilekKarabulut, Aysun BayOtlu, Onder2024-08-042024-08-0420150003-32191945-7103https://doi.org/10.2319/110113-798.1https://hdl.handle.net/11616/96709Objective: To determine the total oxidant status (TOS), total antioxidant status (TAS), and the 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels and their interrelationship in the saliva of children undergoing fixed orthodontic therapy. Materials and Methods: Thirty children were randomly divided into three groups. The attachments were bonded to all of the teeth using three different orthodontic composites: Transbond XT, Kurasper F, and GrenGloo. The salivary levels of TOS, TAS, and 8-OHdG were determined three times, as follows: before treatment (T-1) and at 1 month (T-2) and 3 months (T-3) following appliance placement. All data were statistically analyzed. Results: There were no significant differences in TOS, TAS, and 8-OHdG within the same time periods among the three different orthodontic composites (P > .05). TAS in all composite groups decreased over time. These decreases were found to be significant for Kurasper F and GrenGloo at the T1 T3 and T2 T3 time periods (P < .05). In all composite groups 8-OHdG decreased between T1 and T2 (P < .05). However, 8-OHdG in all composite groups increased from T2 to T3. These differences in 8-OHdG were significant in Kurasper F and GrenGloo (P < .05). Conclusions: Fixed orthodontic appliances bonded with the tested composites did not increase the cytotoxicity markers in saliva.eninfo:eu-repo/semantics/openAccessTotal oxidant statusTotal antioxidant status8-Hydroxy-2 '-deoxyguanosineArticle8522392442494991010.2319/110113-798.12-s2.0-84924865802Q1WOS:000350531200010Q2