Harputluoglu, Murat M. M.Demirel, UlviGul, MehmetTemel, IsmailGursoy, SuleSelcuk, Engin BurakAladag, Murat2024-08-042024-08-0420120360-3997https://doi.org/10.1007/s10753-012-9465-2https://hdl.handle.net/11616/95809Intestinal bacterial overgrowth (IBO) and increased mucosal permeability are suggested to increase bacterial translocation (BT) in liver injury. Rifaximin (RIF) is a minimally absorbed oral antimicrobial agent that restores gut microflora imbalance. The aim of the present study was to investigate the effects of RIF on BT frequency in thioacetamide (TAA)-induced liver injury. Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA + RIF), RIF was commenced on the same day as the first dose of TAA. In group 4 (RIF), rats received only RIF. Ileal aspirate Escherichia coli counts were significantly lower in the TAA + RIF group than in TAA group. There was no difference in BT frequency between the TAA and TAA + RIF groups. Our results suggest that factors such as intestinal barrier dysfunction and impaired host immune shield, apart from IBO, play an important role in BT in this model.eninfo:eu-repo/semantics/closedAccessrifaximinbacterial translocationthioacetamideliver injuryArticle354151215172252714610.1007/s10753-012-9465-22-s2.0-84866740450Q2WOS:000306547400034Q3