Cenesiz, S.Yarim, G. F.Karabulut, A. B.Ara, C.2024-08-042024-08-0420070341-6593https://doi.org/10.2377/0341-6593-114-345https://hdl.handle.net/11616/94416The aim of this study was to evaluate the role of antioxidant enzyme activity and nitric oxide levels induced by 28 day biliary obstruction in the rat. A total of 21 young Swiss albino rats were divided in to 3 groups. Bile duct ligations, bile duct ligations plus resveratrol, sham operated. Bile duct ligations plus resveratrol group received 10 mg/kg dose of resveratrol intraperitonealy once daily throughout for 28 days. Liver damage and cholestasis were determined by biochemical examination. SOD, CAT and GSH-PX activity decreased in BDL group compared with shame opareted groups (p < 0.001). NO levels increased in BDL groups compared with shame opareted groups (p < 0.001). SOD, CAT and GSH-PX activity was found higher in BDL+resveratrol treated groups than BDL groups (p < 0.001). In addition this NO levels decreased in BDL+resveratrol treated groups than BDL groups (p < 0.001). In conclusion, it is thought that resveratrol may be used as a protective agent in biliary obstructions; however, further clinical and experimental studies are needed to verify its antioxidative and hepatoprotective effects.eninfo:eu-repo/semantics/closedAccessbile duct ligationsbiliary cirrhosisfibrosisoxidative stressresveratrolArticle11493453481792707510.2377/0341-6593-114-3452-s2.0-37349117985N/AWOS:000249805600003Q3