Kalcik, AysegulKaloglu, NazanKeser, SerhatSahin, Zarife SibelDusunceli, Serpil Demir2026-04-042026-04-0420260022-328X1872-8561https://doi.org/10.1016/j.jorganchem.2025.123975https://hdl.handle.net/11616/109521A series of palladium N-heterocyclic carbene (NHC) complexes including trans-[Pd(NHC)Br2L] (L = C5H5N, 3-ClC5H4N, and N-methylimidazole) and [Pd(NHC)2Br2] have been prepared from {1-(benzyl)-3-(3,5-(bis(tri-fluoromethyl)benzyl)benzimidazolium bromide}. The structures of these new compounds were confirmed by NMR, FT-IR, and elemental analyses. The crystal structures of the dibromo-[1-(benzyl)-3-(3,5-(bis(tri-fluoromethyl)benzyl)benzimidazole-2-ylidene]-(pyridine)-palladium(II) and dibromo-[1-(benzyl)-3-(3,5-(bis (trifluoromethyl)benzyl)benzimidazole-2-ylidene]-(N-methylimidazole)-palladium(II) were determined by single-crystal X-ray diffraction. Palladium complexes were developed as efficient pre-catalysts for direct C4-arylation of 3,5-dimethylisoxazole and aryl bromides. Biological efficiency of trans-[Pd(NHC)Br2L]was evaluated by antioxidant activities like ABTS, OH and DPPH radical scavenging activity assays.eninfo:eu-repo/semantics/closedAccessPalladium complexN -Heterocyclic carbeneDirect C4-arylationIsoxazoleAntioxidant activityArticle104510.1016/j.jorganchem.2025.1239752-s2.0-105024237072Q2WOS:001640819100001Q2