Göğcegöz Gül, IşılKarlıdağ, RıfatCumurcu, Hatice BirgülTürköz, YusufÖzcan, Abdul CemalErdemli, Erman2017-05-192017-05-192013Göğcegöz Gül, I. Karlıdağ, R. Cumurcu, H. B. Türköz, Y. Özcan, A. C. Erdemli, E. (2013). The effect of agoraphobia on oxidative stress in panic disorder. Psychiatry Investigation 10(4), 317–325.1738-3684http://synapse.koreamed.org/DOIx.php?id=10.4306/pi.2013.10.4.317https://hdl.handle.net/11616/6907We aimed to investigate whether agoraphobia (A) in panic disorder (PD) has any effects on oxidative and anti-oxidative parameters. We measured total antioxidant capacity (TAC), paraoxonase (PON), arylesterase (ARE) antioxidant and malondialdehyde (MDA) oxidant levels using blood samples from a total of 31 PD patients with A, 22 PD patients without A and 53 control group subjects. There was a significant difference between the TAC, PON, ARE and MDA levels of the three groups consisting of PD with A, PD without A and the control group. The two-way comparison to clarify the group creating the difference showed that the TAC, PON, and ARE antioxidants were significantly lower in the PD with A group compared to the control group while the MDA oxidant was significantly higher. There was no significant difference between the PD without A and control groups for TAC, PON, ARE and MDA levels. We clearly demonstrated that the oxidative stress and damage to the anti-oxidative mechanism are significantly higher in the PD group with A. These findings suggest that oxidative/anti-oxidative mechanisms may play a more important role on the pathogenesis of PB with A.eninfo:eu-repo/semantics/openAccessAgoraphobiaFree radicalPanic disorderOxidative stressTotal antioxidant capacityArticle10431732510.4306/pi.2013.10.4.317