Yılmaz, ErcanGül, MehmetMelekoğlu, RaufKöleli, Işıl2019-07-172019-07-172018Yılmaz, E. Gül, M. Melekoğlu, R. Köleli, I. (2018). Immunhistochemical analysis of nuclear factor kappa beta expression in etiopathogenesis of ovariantumors. Cilt:33 Sayı:7, 641-650 ss.https://hdl.handle.net/11616/12667Purpose: To investigate the place of the transcription factor nuclear kappa B (NF-kappa B), which is a marker of chronic inflammation, in the etiology of the ovarian carcinoma. Methods: NFkB analysis with the immunohistochemical method has been performed. To evaluate immunohistochemical NF-kappa B expression in the ovarian tissue, the H-score method. H-score = Sigma Pi (i+1), where "Pi'' is the percentage of stained cells in each intensity category (0-100%) and "i'' is the intensity indicating weak (i=1), moderate (i=2) or strong staining (i=3). Results: It has been seen that, the mean H score is statistically significantly higher in the patient group with serous and musinous adenocarcinoma diagnosis than the two other patient groups (p<0.005). Conclusions: Factor nuclear kappa B is an important mediator that acts in the chronic inflammation. The highest expression rates are determined by the immunohistochemical method in the ovarian cancer group.eninfo:eu-repo/semantics/openAccessCell-GrowthCancerPolymorphısmsProgressıonArticle33764165010.1590/s0102-865020180070000009