Demircan M.Cetin S.Uguralp S.Sezgin N.Karaman A.Gozukara E.M.2024-08-042024-08-0420041015-9584https://doi.org/10.1016/S1015-9584(09)60056-7https://hdl.handle.net/11616/90814Early diagnosis of perforated appendicitis is important for reducing morbidity rates. The aim of this study was to determine the value and utility of plasma D-lactic acid levels in identifying the type of appendicitis. In this clinical study, plasma D-lactic acid levels were assessed in 44 consecutive paediatric patients (23 with acute appendicitis, 21 with perforated appendicitis) before laparotomy. D-lactic acid levels were determined by an enzymatic spectrophotometric technique using a D-lactic acid dehydrogenase kit. Patients with perforated appendicitis had higher D-lactic acid levels (3.970 ±0.687 mg/dL) than patients in the control group (0.478 ± 0.149 mg/dL) and patients with acute appendicitis (1.409 ±0.324 mg/dL; p < 0.05). For a plasma D-lactic acid level greater than 2.5 mg/dL, the sensitivity and specificity of the D-lactic acid assay were 96% and 87%, respectively. The positive predictive value was 87%, the negative predictive value was 96%, and the diagnostic value was 91%. These results suggest that the measurement of plasma D-lactic acid levels may be a useful adjunct to clinical and radiological findings in distinguishing perforated from acute non-perforated appendicitis in children.eninfo:eu-repo/semantics/closedAccessdextro lactate dehydrogenasedextro lactic acidlactic acidunclassified drugacute appendicitisadolescentappendix perforationarticlechildclinical articlecontrolled studydiagnostic accuracydiagnostic valueearly diagnosishumanlactate blood levellaparotomypredictionsensitivity and specificityspectrophotometryArticle2743033051556418410.1016/S1015-9584(09)60056-72-s2.0-7044239112Q2