Celik, EbruKaraer, AbdullahTurkcuoglu, IlginTurhan, UgurGungoren, ArifTaskapan, CagatayOzyalin, Fatma2024-08-042024-08-0420141476-70581476-4954https://doi.org/10.3109/14767058.2013.849239https://hdl.handle.net/11616/96483Objective: To evaluate whether serum folic receptor alpha levels are changed in women whose previous pregnancies were complicated with neural tube defects (NTDs). Methods: This was a case-control study that included 41 women as the control group who had previously had at least one healthy pregnancy and 37 women as the study group who had a previous pregnancy complicated with NTDs. Blood samples were obtained from all of the participants six weeks after the termination of pregnancy or delivery of a baby. Serum folate receptor alpha concentrations were analyzed using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. Results: The mean concentrations of serum folate receptor alpha were significantly lower in the NTD cases compared to those in the control group (p = 0.02). There was no significant difference in mean serum folate titers between the NTD cases and the control group (p = 0.07). Conclusion: Low serum folic acid receptor alpha levels in the current study did not appear to be a regulatory marker of maternal folate homeostasis per se but rather a factor that contributed to the development of NTDs.eninfo:eu-repo/semantics/closedAccessFolatefolic acid receptor alphamaternal serumneural tube defectArticle2711108310872409430410.3109/14767058.2013.8492392-s2.0-84902989760Q2WOS:000337901700001Q3