Kılıç, SüleymanKaradag, N.Ergin, H.Altunoluk, B.2020-07-162020-07-162014Kilic, S., Karadag, N., Ergin, H., Altunoluk, B. Effects of goserelin treatment on microvessel density and blood loss associated with transurethral resection of the prostat. (2014). Journal of Clinical and Analytical Medicine.1309-07201309-2014https://doi.org/10.4328/JCAM.1294https://hdl.handle.net/11616/17017https://search.trdizin.gov.tr/yayin/detay/184352Journal of Clinical and Analytical Medicine Volume 5, Issue 3, May 2014, Pages 229-233Aim: To determine the effects of one dose goserelin before transurethral resection of the prostate (TUR-P) on blood loss and microvessel density (MVD) of prostatic suburethral tissues in the patients with benign prostatic hyperplasia (BPH). Material and Method: The patients who planned to have a TUR-P were randomly divided into two groups. Group-1 consisted of 18 patients who were pretreated with 3,6 mgr subcutaneous injection of goserelin acetate one month before the operation. Group-2 was constructed from 21 patients without goserelin acetate pretreatment. The amount of intraoperative haemorrhage was calculated. Total blood loss, total blood loss/duration of surgery and total blood loss/gram of resected tissue were calculated for each patient. Sections from the prostatic suburethral tissues were examined for microvessel density. Results: Quantitative decreases in Hb were greater in group 1 than in group 2, and mean Hb level was statistically significantly lower in group 1 than in group 2 at the control just after the operation (p=0.028). Although all the differences were statistically insignificant, Hb concentration in irrigation fluid and total blood loss during surgery were higher in the group 1 than in the group 2, contrarily, blood loss by duration of TURP and blood loss by weight of resected prostate tissue were less in the group 1 than in the group 2. The MVD was significantly lower in group 2 than in the group 1. Discussion: Single dose goserelin treatment given for one month is not effective in reducing blood loss during TURP and has not suppressive effects on MVD in prostatic tissues.eninfo:eu-repo/semantics/openAccessBenign prostatic hyperplasiaBlood lossMicrovessel densityTransurethral resection of prostateArticle5322923310.4328/JCAM.12942-s2.0-84900313177N/A184352WOS:000215562200017N/A