Karatas, MerveSimsek, Murat2026-04-042026-04-0420250021-89951097-4628https://doi.org/10.1002/app.57705https://hdl.handle.net/11616/110008This study explores the optimization of electrospun Eudragit L100 (EL100) fibers by examining how fiber morphology (random vs. aligned), core-shell architecture, and solvent systems influence their physicochemical and degradation behavior. Fibers were produced using ethanol (EtOH) or methanol (MeOH) with dimethylformamide (DMF) as a co-solvent, at varying polymer concentrations and solvent ratios. DMF incorporation improved electrospinnability, enabling smooth, bead-free fibers at >= 15 wt% polymer content, whereas higher concentrations (25 wt%) yielded ribbon-like structures due to delayed solvent evaporation. Aligned fibers, obtained via rotating collector, showed significantly enhanced mechanical properties, with tensile strength and elastic modulus values up to 10-fold greater than those of random fibers. Swelling and degradation behavior, tested in pH 1.2, 6.8, and 7.4 media, revealed structure-dependent stability: aligned and thicker fibers resisted degradation, whereas thinner, random fibers degraded more rapidly. Core-shell fibers containing chitosan or guar gum exhibited greater swelling (119%-122%) and potential for improved drug loading. In vitro release studies using methylene blue demonstrated low release in acidic medium and structure-dependent release at intestinal pH. These findings highlight the importance of structural design in tailoring EL100-based fibers for biomedical applications such as colon-targeted drug delivery and bioresorbable scaffolds.eninfo:eu-repo/semantics/closedAccesscopolymersdrug delivery systemselectrospinningfibersArticle1424410.1002/app.577052-s2.0-105011935218Q2WOS:001536168200001Q30000-0002-6301-5184