Karatas, Mert OlgunAlici, BulentCakir, UmitCetinkaya, EnginDemir, DuduErgun, AdemGencer, Nahit2024-08-042024-08-0420131475-6366https://doi.org/10.3109/14756366.2012.677838https://hdl.handle.net/11616/96298A newly series of water-soluble 1-alkyl-3-(4-methyl-7, 8-dihydroxy-2H-chromen-2-one) benzimidazolium chloride salts (3a-j) were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and II were evaluated. hCA I and II from human erythrocytes were purified by a simple one step procedure by using Sepharose 4B-L-tyrosine-sulphanilamide affinity column. The result showed that all the synthesized compounds were inhibited the CA isoenzymes activity. Among them, 3g and 3j were found to be most active (IC50 = 22.09 mu M and 20.33 mu M) for hCA I and hCA II, respectively.eninfo:eu-repo/semantics/openAccessCarbonic anhydrasecoumarinbenzimidazoliuminhibitionArticle2822993042251272710.3109/14756366.2012.6778382-s2.0-84889677128N/AWOS:000314531000009Q3