Karatas, Mert OlgunCalgin, GamzeAlici, BulentGokce, BasakGencer, NahitTok, Tugba TaskinArslan, Oktay2024-08-042024-08-0420190268-26051099-0739https://doi.org/10.1002/aoc.5130https://hdl.handle.net/11616/98980We synthesized three coumarin-substituted benzimidazolium chlorides and their silver(I), ruthenium(II) and palladium(II) N-heterocyclic carbene (NHC) complexes. All compounds were characterized using appropriate spectroscopic techniques and elemental analyses. Single-crystal X-ray structure of a Pd(II)-NHC complex (6b) was also determined. The inhibitory properties of all compounds were tested on the activity of human paraoxonase 1 (PON1). All complexes exhibited weaker inhibitory properties than their corresponding benzimidazolium salts except for complex 6b which is the most active inhibitor with an IC50 value of 3.01 mu M among the compounds reported in this study. A kinetic evaluation showed that this complex inhibits PON1 activity in a non-competitive manner. Molecular docking studies were also performed for 6b in order to obtain more insight into the binding mode.eninfo:eu-repo/semantics/closedAccesscoumarininhibitionN-heterocyclic carbenesparaoxonase 1Article331010.1002/aoc.51302-s2.0-85073488159Q2WOS:000478234900001Q1