Akıncı, AyşehanÇetin, Dilekİlhan, Nevin2017-07-102017-07-102012AKINCI, A., ÇETİN, D., & İLHAN, N. (2012). Plasma kisspeptin levels in girls with premature thelarche. J Clin Res Pediatr Endocrinol , 4(2), 61–65.https://www.ncbi.nlm.nih.gov/pubmed/21534336https://hdl.handle.net/11616/7366J Clin Res Pediatr EndocrinolGonadotropin-releasing hormone analog (GnRHa) therapy is used in idiopathic central precocious puberty (ICPP) worldwide. It has also been shown that during this therapy, body mass index (BMI) increases slightly as a side effect. We investigated the side effects of GnRHa treatment in ICPP on body composition and insulin resistance (IR). Twenty girls (7.55 +/- 1.02 y) with ICPP were treated with GnRHa (leuprolide) for an average of 20.83 +/- 4.8 months. Bioelectrical Impedance Analysis (BIA) was used to measure the body's fat balance. Nine patients out of 20 (45%) had significant gain weight. We showed a significant elevation in trunk fat mass compare to baseline values (p < 0.01). These nine patients had high homeostasis model assessment (HOMA)-IR and low glucose/insulin (G/I) index. This study showed a slight increase in BMI, moderate increase in total body fat, and exaggerated elevation in trunk fat mass and IR in GnRHa-treated ICPP children.eninfo:eu-repo/semantics/openAccessArticle426165