Baysal, TamerÖzışık Karaman, Handan IşınKarlıdağ, RıfatSaraç, KayaBaysal, ÖzlemDusak, AbdurrahimHazneci, ErsoyÖzcan, Abdulcemal2017-05-262017-05-262003:Baysal, T. Özışık Karaman, H. I. Karlıdağ, R. Saraç, K. Baysal, Ö. Dusak, A. Hazneci, E. Özcan, A. (2003). Proton MRS in Behcet s disease with and without neurological findings. Neuroradiology, 45(12), 860–864.0028-3940http://link.springer.com/10.1007/s00234-003-1052-7https://hdl.handle.net/11616/6933Abstract Our aim was to investigate whether neurological impairment in Behc¸et s disease (BD) can be assessed by means of proton MRS and whether it can assist in prognosis. We used single-voxel MRS to measure metabolites in regions of normal-appearing pons, basal ganglia and periventricular white matter (PWM) in 32 patients with chronic BD patients with and without neurological deficits and 29 control subjects. Patients had significantly higher N-acetylaspartate (NAA)/ creatine (Cr) and choline (Cho)/Cr ratios in the basal ganglia than the controls. The Cho/Cr ratio in the PWM was also significantly higher in the patients. MRS enabled clear discrimination of patients and controls and also revealed spectral differences between non-neuro-Behc¸et s disease and neuro-Behc¸et s disease in the basal ganglia. MRS can be used to assess brain involvement in BD even if structural changes are absent.eninfo:eu-repo/semantics/openAccessBehçet's diseaseBrainMagnetic resonance spectroscopyArticle451286086410.1007/s00234-003-1052-7