Karatas, Mert OlgunTekin, SuatAlici, BulentSandal, Suleyman2024-08-042024-08-0420190974-36260973-7103https://doi.org/10.1007/s12039-019-1647-0https://hdl.handle.net/11616/98893Coumarin and benzimidazole derivatives have individual biological activities including anticancer. In this study, we aimed to synthesize coumarin-benzimidazole hybrids in order to investigate their anticancer properties. For this purpose, six 6-substituted-4-chloromethylene coumarin derivatives were synthesized. Sixteen coumarin substituted benzimidazolium chlorides were synthesized by the reaction of 4-chloromethylene coumarin and N-benzylbenzimidazole derivatives. All of the synthesized compounds were characterized by 1H and 13C NMR, IR spectroscopic techniques and elemental analyses. Cytotoxicities of all compounds were tested by [ 3-(4,5-dimethylthiazole)-2-yl]-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay against human prostate (PC-3) and ovarian (A2780) cancer cells. All compounds performed significant cytotoxicities at 100 mu Magainst both cancer cell lines. Moreover, some compounds performed significant activities at 1 mu M against both cancer cell lines and the obtained results suggest that this type of compounds are promising candidates for the treatment of human prostate and ovarian cancers.eninfo:eu-repo/semantics/openAccessBenzimidazolebenzimidazolium saltcoumarincytotoxicityArticle131810.1007/s12039-019-1647-02-s2.0-85070019596Q3WOS:000480284000001Q3