Sari, YakupAktas, AydinTaslimi, ParhamGok, YetkinGulcin, Ilhami2024-08-042024-08-0420181095-66701099-0461https://doi.org/10.1002/jbt.22009https://hdl.handle.net/11616/98032The novel N-propylphthalimide-substituted and 4-vinylbenzyl-substituted N-heterocyclic carbene (NHC) precursors were synthesized by N-substituted benzimidazolium with aryl halides. The novel N-propylphthalimide-substituted and 4-vinylbenzyl-substituted NHC precursors have been characterized by using H-1 NMR, C-13 NMR, FTIR spectroscopy, and elemental analysis techniques. They were tested for the inhibition of AChE and hCA enzymes and demonstrated efficient inhibition profiles with K-i values in the range of 351.0-1269.9 nM against hCA I, 346.6-1193.1 nM against hCA II, and 19.0-76.3 nM against AChE. On the other hand, acetazolamide, a clinically used molecule, utilized as CA inhibitor, obtained a K-i value of 1246.7 nM against hCA I and 1407.6 nM against hCA II. Additionally, tacrine inhibited AChE and obtained a K-i value of 174.6 nM.eninfo:eu-repo/semantics/closedAccessacetylcholinesterasebenzimidazolecarbonic anhydrasemetal chelatingN-heterocyclic carbene precursorsArticle3212914953410.1002/jbt.220092-s2.0-85034266466Q2WOS:000419943200011Q2