Demir, TolgaBaris, AyseSigirci, SerhatSigirci, Buket BambulTanriverdi, Elif SerenKoramaz, Ismail2024-08-042024-08-0420231054-88071879-1336https://doi.org/10.1016/j.carpath.2022.107467https://hdl.handle.net/11616/100927Chaetomium globosum is a dematiaceous, filamentous fungus belonging to the large genus saprobic as-comycetes and is rarely involved in human infection. We present the case of a 25-year-old man undergo-ing tricuspid valve replacement due to recurrent prosthetic ring endocarditis. Initially, it was considered culture-negative endocarditis; however, the diagnosis of Chaetomium globosum could only be provided by DNA isolation of the mold isolate grown in culture and the valve tissue samples taken from the pa-tient. This report describes the first documented tricuspid endocarditis caused by Chaetomium species and discusses the importance of molecular tools to enhance the diagnostic process in culture-negative endocarditis, especially for fastidious and nonculturable microorganisms. (c) 2022 Elsevier Inc. All rights reserved.eninfo:eu-repo/semantics/closedAccessInfective endocarditisFungal endocarditisTricuspid valveChaetomium globosumArticle623597048610.1016/j.carpath.2022.1074672-s2.0-85139345217Q1WOS:000975317400001Q2