Özcan, Canan CeranSönmez, KaanTürkyılmaz, zaferDemiroğulları, BillurDursun, Ayşe2017-12-152017-12-152001Ceran Özcan, C., Sönmez, K., Türkyılmaz, Z., Billur, Demiroğulları, Dursun, A., Ersel, D., … Nuri, K. (2001). Effect Of Bilirubin İn İschemia Reperfusion İnjury On Rat Small İntestine. Journal Of Pediatric Surgery, 36(12), 1764–1767.https://ac.els-cdn.comhttps://hdl.handle.net/11616/7893Journal of Pediatric Surgery, Vol 36, No 12 (December), 2001: pp 1764-1767.Purpose: The aim of this study was to determine the effects of bilirubin in experimental small intestinal ischemia/reperfusion (I/R) injury in rats. Methods: Thirty rats were divided into 5 groups (n 5 6). In group S, saline and in group B, bilirubin, 20 mg/kg were infused via the jugular vein without an additional procedure. In groups S-IR, saline, B1-IR and B2-IR, 10 and 20 mg/kg/h of bilirubin were infused for 2 hours, respectively. In these groups, an I/R procedure was done after infusions by occluding the superior mesenteric artery for 45 minutes followed by 1 hour of reperfusion. After reperfusion, the small intestines were resected for histopathologic and malondialdehyde (MDA) assessments. Mucosal lesions were scored between 0 and 5. Malondialdehyde levels and histopathologic grades were analyzed statistically.eninfo:eu-repo/semantics/openAccessBilirubinİschemiaReperfusion injuryİntestineArticle36121764176710.1053/jpsu.2001.28816