Ulu, AhmetBirhanli, EmreAtes, Burhan2024-08-042024-08-0420210141-81301879-0003https://doi.org/10.1016/j.ijbiomac.2021.08.068https://hdl.handle.net/11616/100137Herein, tannic acid (TA)-reinforced chitosan (CHS)/beta-cyclodextrin (beta-CD) biocomposite membranes were prepared by TA solution incubating treatment. The functional groups, crystal structure, and morphological characterizations of the prepared biocomposite membranes were investigated using various methods. The biocomposite membranes were investigated in terms of their wettability, porosity, swelling degree, and water uptake. In vitro antioxidant investigation was carried out through DPPH assay. Moreover, the prepared biocomposite membranes were evaluated for their antimicrobial ability against three different microbial species. The introduction of TA effectively improved the swelling behavior, mechanical strength, and porosity of the biocomposite membranes. TA increased the tensile strength from 0.7 +/- 0.2 MPa to a maximum of 2.2 +/- 0.6 MPa and elongation at break from 26.9 +/- 0.7% to a maximum of 36.7 +/- 3.5%. The biocomposite membranes showed an initial burst release of TA (similar to 40%) within 6 h, followed by a gradual release of 100% by 18 h. Furthermore, the introduction of TA into the biocomposite membranes further improved the antimicrobial activities against both bacteria and yeast, as well as the in vitro antioxidant potential. As a consequence, the prepared biocomposite membranes could potentially be used as scaffold in broaden biomedical fields due to their adaptable structure, porosity, greatly antioxidant, and antimicrobial activity.eninfo:eu-repo/semantics/closedAccessChitosanTannic acidbeta-CyclodextrinBiocompositeAntioxidantAntimicrobial activityArticle1886967073440023210.1016/j.ijbiomac.2021.08.0682-s2.0-85112748285Q1WOS:000697936100006Q1