Eşrefo?lu M.Uçar M.2024-08-042024-08-0420021016-5134https://hdl.handle.net/11616/90819High endothelial venules are specialized postcapillary venules localized in lymphatic tissue, including lymph nodes and lymphatic tissues associated with digestive tract and respiratory tree. However, in chronically inflamed tissues, as skin, gut or synovium endothelial cells from the venules may acquire high endothelial venule-like caharacteristics. The endothelial cells of high endothelial venules are called high endothelial cells by reference to their typical plump, almost cuboidal morphology, very different from the flat appearance of endothelial cells that line other vessels. High endothelial cells have a prominent Golgi apparatus, well-developed granular endoplasma reticulum, many mitochondria, vesicles, multivesicular bodies and Weibel-Palade. They have a high secretory activity in contrast to the weak activity of ordinary endothelial cells. In this review light and electron microscopic, histochemical and physiological features of high endothelial venules are rewieved.trinfo:eu-repo/semantics/closedAccesscell activitycell structureelectron microscopyendoplasmic reticulumendotheliumendothelium cellGolgi complexhistochemistrymembrane vesiclemitochondrionshort surveyvenuleWeibel Palade bodyShort Survey1481151182-s2.0-0036669828N/A