Ozen, IrsatTogal, TurkanAydogan, Mustafa SaidErdogan, Mehmet AliNakir, HamzaGulhas, NurcinToprak, Huseyin Ilksen2024-08-042024-08-0420121840-22911986-8103https://hdl.handle.net/11616/95890Introduction: Various fluids used for preloading purposes prior to spinal anesthesia. Coagulation disorders can occur due to use of those fluids at large volumes [1]. We aimed to compare the impact of different preloading fluids over coagulation parameters. Method: Sixty-eight patients of ASA I-II physical status who were aged between 18 and 75 years, and scheduled for orthopedic surgery under spinal anesthesia, were included in the study. Prior to the spinal anesthesia, preloading was carried out by RL in Group R (n=16), HES (130/0.4) in Group H (n=16), polygeline in Group P (n=16), and succinylated gelatin 7 ml/kg in Group S (n=16). RL was used as the maintenance fluid in all the groups. Thromboelastography, CBC, PTT, aPTT, fibrinogen values were assessed at baseline and 2 hours. Results: Groups P and S displayed significantly prolonged PTT values. While Groups R and P showed significantly prolonged PTT-INR values, groups R and H exhibited significantly prolonged aPTT values. Groups R, P, and S demonstrated significant decreases in TEG parameters including R, K, CI, and TMA. The increase in a angle was significant in groups R and S. Conclusion: Fluid preloading with HES was not found to affect the coagulation parameters, however, polygeline and succinylated gelatin were observed to cause moderate hypercoagulation. Therefore, we believe that HES may be preferred over succinylated gelatin and polygeline in cases with hypercoagulability.eninfo:eu-repo/semantics/closedAccessHypercoagulabilitythromboelastographypreloading fluidspinal anesthesiaArticle610348834932-s2.0-84871252188N/AWOS:000312158300037N/A