Cidem, MuharremKarakoc, YunusEkmekci, HakanKucuk, Suat HayriUludag, MuratGun, KeremKaramehmetoglu, Safak Sahir2024-08-042024-08-0420141300-01441303-6165https://doi.org/10.3906/sag-1302-88https://hdl.handle.net/11616/96404Background/aim: To determine whether plasma sclerostin levels are affected by applying whole-body vibration treatments. Materials and methods: Following a pilot study, the present prospective, randomized, controlled single-blind study was performed on 16 healthy volunteer women (ages 20 to 40 years). Subjects were randomly divided into 2 groups, and whole-body vibration was applied to the treatment group but not to the controls. The plasma sclerostin levels were measured before the treatment and at the 10th minute after whole-body vibration on the 1st, 2nd, and 5th days of application. Results: The plasma sclerostin level measured at 10 min after the whole-body vibration treatment increased 91% (P = 0.024) on the 1st day and decreased 31.5% (P = 0.03) on the 5th day in the whole-body vibration group. In the control group, there was no change in the plasma sclerostin level at any time. A progressive increase in baseline plasma sclerostin levels during the 5 days of vibration sessions was also found. Conclusion: Our study demonstrated that whole-body vibration can change plasma sclerostin levels, and that this change is detectable 10 min after whole-body vibration treatments.eninfo:eu-repo/semantics/openAccessSclerostincyclic mechanical loadingvibrationosteocyteboneArticle4434044102555864110.3906/sag-1302-882-s2.0-84897909464Q3WOS:000334063700010Q4