Kirici, P.Cagiran, F. T.Kali, Z.Tanriverdi, E. F.Mavral, N.Ecin, S. M.2024-08-042024-08-0420231128-3602https://hdl.handle.net/11616/101241OBJECTIVE: To evaluate ma-ternal serum inflammatory marker changes in intrauterine growth restriction (IUGR) preg-nancies.PATIENTS AND METHODS: 50 healthy preg-nant women and 50 patients diagnosed with IU-GR were enrolled. Maternal serum high sensi-tivity C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), tumor necrosis fac-tor-alpha (TNF-alpha), interleukin (IL)-6, and IL-10 levels were measured before delivery and neonatal outcomes were evaluated.RESULTS: Birth weight, Apgar scores, and cord blood gas pH were lower in the IUGR group (p<0.001, p<0.001, p<0.001 and p=0.006, respectively). While the levels of ESR, hsCRP, IL-6, and TNF-alpha were higher, the IL-10 level was found to be lower in the IUGR group (p<0.001, p=0.033, p<0.001, p=0.004 and p<0.001, re-spectively). As ESR, hsCRP, and IL-6 levels in-creased, birth weight, Apgar scores, and cord blood gas pH decreased (p<0.001, p<0.001, p<0.001, p<0.001, p=0.02, p=0.002, p=0.001, p=0.03, p<0.001, p<0.001, p<0.001 and p=0.02, respectively). As TNF-alpha level increased, only birth weight and Apgar score at the 1st minute decreased (p=0.006 and p=0.048, respective-ly). As IL-10 level decreased, birth weight, Ap-gar scores, and cord blood gas pH decreased (p<0.001 for all). IL-6 (>3.2 pg/ml) had a sensi-tivity of 100%, specificity of 100%, PPV of 100% and NPV of 100%.CONCLUSIONS: While birth weight, Apgar score and cord blood pH decreased in IUGR cas-es, ESR, hsCRP, IL-6 and TNF-alpha levels increased. Combined measurement of these markers can be used for the diagnosis of IUGR.eninfo:eu-repo/semantics/closedAccessKey Intrauterine growth restrictionIL-6IL-10TNF-al-phaArticle27519962001369304982-s2.0-85150666096Q2WOS:000959553700034N/A