Alkan, AlpaySaraç, KayaKutlu, RamazanYakıncı, Mehmet CengizSığırcı, AhmetAslan, MehmetBaysal, Tamer2017-06-242017-06-242003Alkan, A. Saraç, K. Kutlu, R. Yakıncı, M. C. Sığırcı, A. Aslan, M. Baysal, T. (2003). Early and late state subacute sclerosing panencephalitis chemical shift imaging and single voxel MR spectroscopy. AJNR. 24:501–506.https://hdl.handle.net/11616/7182Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, inflammatory neurodegenerative disease. Our aim was to determine the metabolic abnormalities of brain in early- and late-stage SSPE by using MR spectroscopy and to assess areas of involvement in the early stages when MR imaging findings were normal. METHODS: Children with stage II (n 3) or III (n 3) SSPE and 10 healthy, age-matched children underwent MR imaging, multivoxel MR spectroscopy, and short-echo single-voxel MR spectroscopy (SVS). Areas of involvement in the brain were determined with chemical shift imaging. For SVS, 2 2 2-cm voxels were placed in the frontal subcortical white matter (FSWM) and parieto-occipital white matter (POWM). N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, myo-inositol (Ins)/Cr, and NAA/Cho ratios were calculated. RESULTS: Comparisons of NAA/Cr, Cho/Cr, Ins/Cr and NAA/Cho ratios between patients and control subjects showed significant differences in FSWM and POWM (P < .01). In patients with SSPE, NAA/Cr ratios in POWM were significantly less than those in FSWM (P < .01). NAA/Cr ratios in patients with stage II SSPE and those in the control group were not significantly different; this may reflect the absence of neuronal loss. Decreased NAA/Cr, increased Cho/Cr and Ins/Cr ratios, and increased lactate and lipid peaks were found in patients with stage III SSPE. CONCLUSION: MR spectroscopy showed findings suggestive of inflammation in stage II and findings of demyelination, gliosis, cellular necrosis, and anaerobic metabolism in stage III. MR spectroscopy could be a promising technique for early diagnosis and treatment planning in cases of SSPE.eninfo:eu-repo/semantics/openAccessArticle24501506