Ara, CengizEşrefoğlu, MukaddesPolat, AlattinIşık, BurakAladağ, MuratGül, MehmetAy, SelmaTekerekoğlu, Mehmet SaitYılmaz, Sezai2017-08-102017-08-102006Ara, C. Eşrefoğlu, M. Polat, A. Işık, B. Aladağ, M. Gül, M. Ay, S. Tekerekoğlu, M. S. Yılmaz, S. (2006). The effect of caffeic acid phenethyl ester on bacterial translocation and intestinal damage in cholestatic rats. Digestive Diseases and Sciences, 51(10), 1754–1760.0163-2116http://link.springer.com/10.1007/s10620-006-9130-4https://hdl.handle.net/11616/7518Abstract We investigated the effect of caffeic acid phenethyl ester in rat ileum injury induced by chronic biliary obstruction. Swiss albino rats were divided into three groups: Group 1, sham (n = 7); Group 2, common bile duct ligation (n = 7); and Group 3, common bile duct ligation plus caffeic acid phenethyl ester (n = 7). In the caffeic acid phenethyl ester-treated rats, ileum tissue levels of malondialdehyde and myeloperoxidase were significantly lower than those of the bile duct-ligated rats (P < 0.001). The levels of tumor necrosis factor-α, interleukin-6, and interleukin-1α in the caffeic acid phenethyl ester group were significantly lower than those in the bile duct ligation group (P < 0.03, P < 0.01, and P < 0.02 respectively). The present study demonstratesthat intraperitoneal administration of caffeic acid phenethyl ester in bile duct-ligated rats reduces intestinal oxidative stress. This effect may be useful in the preservation of intestinal damage in cholestasis.eninfo:eu-repo/semantics/openAccessCommon bile duct ligationBacterial translocationCaffeic acid phenethyl esterOxidative stressCytokinesArticle51101754176010.1007/s10620-006-9130-4