Durak, M. A.Ozhan, O.Yildiz, A.Durhan, M.Vardi, N.Cigremis, Y.Parlakpinar, H.2024-08-042024-08-0420221128-3602https://hdl.handle.net/11616/100952OBJECTIVE: This study was performed to investigate the potential benefi- cial effects of thymoquinone (TQ) on brain tis-sue based on biochemical and histopathologi-cal analyses in cisplatin (CIS) treated rats with central nervous system (CNS) neurotoxicity. MATERIALS AND METHODS: The rats were randomly divided into 4 groups with 8 rats in each group (n:8). Group 1: (Control), saline was administered for 3 days at a volume of 0.5 ml per day intraperitoneal (i.p.). Group 2: (CIS Group), one dose of CIS was administered (7 mg/kg i.p.). Group 3: (TQ Group), TQ was giv-en at a dose of 5 mg/kg per day for 3 days (i.p.). Group 4: (CIS+TQ Group), one dose of 7 mg/ kg was initiated half an hour before adminis-tration of CIS and one dose of 5 mg/kg per day was administered TQ i.p. for 3 days. RESULTS: Malondialdehyde levels were found to be statistically significantly higher in the CIS group compared to the control group. Degenerative changes observed in the CIS+TQ group were found to be milder than in the CIS group. In the CIS+TQ group, a statistically sig-nificant decrease in the severity of caspase-3 immunoreactivity was found when compared to the CIS group. It was found that the sever-ity of neurofilament immunoreactivity moni- tored in neuronal extensions was similar in all groups. In the CIS+TQ group, the severity of tau protein's immunoreactivity was similar to that of the CIS-group.CONCLUSIONS: According to the results obtained in our study, beneficial effects were obtained in reducing neurotoxicity with short-term TQ application in rats treated with CIS treatment.eninfo:eu-repo/semantics/closedAccessThymoquinoneCisplatinNeurotoxicityOxidative stressRatArticle261969356943362635732-s2.0-85140261865Q2WOS:000877188200009Q2