Bilgiç, YılmazHarputluoğlu, Muhsin Murat MuhipDal, Mehmet BurakBozan, Mehmet BuğraŞahin, AbdurrahmanYazar, Fatih MehmetÇağın, Yasir Furkan2021-12-032021-12-032015BİLGİÇ Y,HARPUTLUOĞLU M. M. M,YAPRAK B,DAL M. B,BOZAN M. B,ŞAHİN A,YAZAR F. M,ÇAĞIN Y. F,OKÇU N (2015). The Relationship Between Hepatic Activity Index and Serum Tumor Necrosis Factor Alpha Levels in Patients with Chronic Active Hepatitis-B and Chronic Active Hepatitis-C. Medicine Science, 4(4), 2772 - 2781.2147-0634https://hdl.handle.net/11616/43811https://search.trdizin.gov.tr/yayin/detay/249488Abstract: In the present study, we investigated the relationship between serum TNF-? levels and hepatic activity in liver biopsies of chronic hepatitis B and C patients.The study was performed on 30 chronic hepatitis B patients, 25 chronic hepatitis C patients and 25 healthy controls. Serum samples of patients who underwent biopsy and healthy controls were collected. Control group was seronegative for hepatitis and had normal liver function tests. TNF- ? levels measured by ELISA. Knodell’s hepatic activity index was used in evaluation of liver biopsies. Serum TNF? levels were determined higher in chronic hepatitis B and C patients than control group. HAI and TNF- ? compared in chronic hepatitis B and C patients. Although we detected a relationship between HAI and TNF-? levels in chronic hepatitis B patients, no true correlation was shown in chronic hepatitis C patients. Cytokines have an important role in progression of chronic hepatitis B and C infections. There is a relationship between hepatic activity index and TNF-? level in chronic hepatitis B infection.But There is not relationship between hepatic activity index and chronic hepatitis C infection.only in two patients and both of them where in the middle of their reproductive age while as symptomatic ovarian cysts was a more common finding in unmarried females in 21-28 years of age group. This study concluded that laparoscopy has a diagnostic as well as a therapeutic implication in management of NSAPeninfo:eu-repo/semantics/openAccessArticle4427722781249488