Kucukbay, F. ZehraBugday, NesrinKucukbay, HasanTanc, MuhammetSupuran, Claudiu T.2024-08-042024-08-0420161475-63661475-6374https://doi.org/10.3109/14756366.2015.1114931https://hdl.handle.net/11616/97063N-protected amino acids were reacted with substituted benzothiazoles to give the corresponding N-protected amino acid-benzothiazole conjugates (60-89%). Their structures were confirmed by proton nuclear magnetic resonance (H-1 NMR), carbon-13 nuclear magnetic resonance (C-13 NMR), IR and elemental analysis. Their carbonic anhydrase (CA, EC 4.2.1.1) inhibitory activities were determined against two cytosolic human isoforms (hCA I and hCA II), one membrane-associated (hCA IV) and one transmembrane (hCA XII) enzyme by a stopped-flow CO2 hydrase assay method. The new compounds showed rather weak, micromolar inhibitory activity against most of these enzymes.eninfo:eu-repo/semantics/closedAccessAmino acid-benzothiazole conjugatesbenzothiazolecarbonic anhydraseArticle316122112252659892710.3109/14756366.2015.11149312-s2.0-84947924827Q1WOS:000385270300045Q1