Yonar, M. E.Ispir, U.Yonar, S. MiseKirici, M.2024-08-042024-08-0420160145-56801165-158Xhttps://doi.org/10.14715/cmb/2016.62.6.10https://hdl.handle.net/11616/97576The aim of this study was to evaluate antioxidant responses of rainbow trout (Oncorhynchus mykiss) exposed to different concentrations of copper sulphate (CuSO4). Fish were exposed to 0 (Group I-control), 5 (Group II), 15 (Group III) and 30 mu g/L (Group IV) concentrations of CuSO4 for 14 days. Liver and gills samples were collected at the end of the experiment, and analysed for their oxidant-antioxidant status, including the malondialdehyde (MDA) level, the catalase (CAT) and glutathione peroxidase (GSH-Px) activities as well as the reduced glutathione (GSH) concentration. Results obtained showed that the levels of MDA increased in tissues of fish. Compared to control, GSH level and GSH-Px and CAT activities were significantly reduced in the fish that were exposed to different concentrations of CuSO4. The result demonstrated that CuSO4 has an oxidative-stress-inducing potential in fish.eninfo:eu-repo/semantics/closedAccessCopper sulphaterainbow troutoxidative stressantioxidant systemArticle62655582726280310.14715/cmb/2016.62.6.102-s2.0-84994879721Q4WOS:000376678600010Q4