Amri, NasserMukhrish, Yousef E.Gatri, RafikGurbuz, NevinOzdemir, IsmailDridi, KhaireddineHamdi, Naceur2024-08-042024-08-0420230449-22852357-0245https://doi.org/10.21608/EJCHEM.2023.122780.5495https://hdl.handle.net/11616/101423The reaction of [RuCl2(p-cymene)]2 with in situ prepared Ag-N-heterocyclic carbene (NHC) complexes yields a series of [RuCl2(p-cymene) (NHC)] complexes 3. The structures of complexes were established by appropriate spectroscopic methods and elemental analyses. The biological activities of the synthesized ligands and their Ru (II) complexes as acetylcholinesterase, antimicrobial, and antioxidant agents were evaluated. The lowest MICs values were obtained with the two complexes 3b and 3d. The enzymatic inhibitory investigation against acetylcholinesterase (AChE) and tyrosinase (TyrE), showed that the two complexes 3b and 3d are the most potent inhibitors against (AchE) with an IC50 of 2.52 and 5.06 & mu;g mL-1 respectively, and against (TyrE) with an IC50 of 19.88 and 24.95 & mu;g mL-1 respectively. Additionally, DPPH (2,2-diphenyl-1-picrylhydrazyl) has been tested for its ability to scavenge hydrogen peroxide and free radicals. According to our results, these compounds exhibiteninfo:eu-repo/semantics/openAccessStrucutre analysisCatalystsCatalysisBiological activityN-Heterocyclic carbenebenzimidazolium saltsruthenium complexessilver complexesFrom Synthesis to Biological Impact of Ru (II) Complexes: Preparation, Characterization, Antimicrobial, Antioxidant scavenging and Enzymatic inhibitory activitiesArticle66520321410.21608/EJCHEM.2023.122780.54952-s2.0-85162860547Q3WOS:001015023000021Q3