Özyurt, HIrmak, MKAkyol, ÖSögüt, S2024-08-042024-08-0420010263-64841099-0844https://doi.org/10.1002/cbf.923https://hdl.handle.net/11616/93325Oxygen-derived free radicals have been implicated in the pathogenesis of renal injury after ischaemia-reperfusion. Caffeic acid phencthyl ester (CAPE), an active component of propolis extract, exhibits antioxidant properties. To investigate whether treatment with either CAPE or alpha-tocopherol modifies the levels of the endogenous indices of oxidant stress, we examined their effects on an in vivo model of renal ischaemia-reperfusion injury in rats. CA-PE at 10 mu mol kg(-1) or alpha-tocopherol at 10 mg kg(-1) was administered intraperitoneally before reperfusion. Acute administration of both CAPE and alpha-tocopherol altered the indices of oxidative stress differently in renal ischaemia-reperfusion injury. Copyright (C) 2001 John Wiley & Sons, Ltd.eninfo:eu-repo/semantics/closedAccesskidneyreperfusion injurycaffeic acid phenethyl esteralpha-tocopherolArticle1942592631174620610.1002/cbf.9232-s2.0-0035192705Q2WOS:000172344400004Q4