Kirat, GokhanErdogan, AliAksan, Mehmet Ali2024-08-042024-08-0420240924-42471873-3069https://doi.org/10.1016/j.sna.2024.115400https://hdl.handle.net/11616/101969We present the results of research on a Co -based giant magnetoimpedance (GMI) biosensor for Fe 3 O 4 -labelled doxorubicin (DOX) anticancer drugs. Co 62 Fe 5 Ni 4 Si 15 B 14 ribbons were used as biosensing material for test solutions containing different concentrations of DOX. The plain ribbon, ribbon +Fe 3 O 4 and ribbon +DOX2 samples exhibited low coercivity ( H c ), high saturation magnetization ( M s ) and low anisotropy ( H k ). The GMI ratio ( Delta Z / Z ) increased from 33% to 38% with the increase of doxorubicin content in the ribbon. It was found that the Delta Z / Z ratio first increased rapidly up to a frequency of -2 MHz, and then decreased slowly as the frequency increased. While the magnetic field dependent Delta Z / Z has a single peak at 1 MHz, it has a double peak at 5 MHz. It was found that the peak height of Delta Z/Z in the ribbons with test solution of 20 ng/ml and 50 ng/ml increased by -3% and -6%, respectively, compared to the ribbon without test solution. Then the Delta Z / Z ratio decreased very rapidly with the increase of the applied external magnetic fields. The frequency -dependent GMI sensitivity ( eta) increased with increasing frequency and reached a maximum value at a critical frequency (-1.6 MHz), after which it decreased. The detection sensitivity of the GMI biosensor ( xi ) increased rapidly with increasing doxorubicin concentration up to -80 ng/ml and then remained almost unchanged. The results show that doxorubicin (DOX +Fe 3 O 4 ), used as an anticancer drug, can be effectively detected even at low concentrations using the GMI based sensors fabricated in this study.eninfo:eu-repo/semantics/closedAccessBiosensorMagnetoimpadanceMagnetic nanoparticleAmorphous ribbonArticle37310.1016/j.sna.2024.1154002-s2.0-85192261448Q1WOS:001239317400001N/A