Firat, Penpe GulDemirel, Ersan ErsinDemirel, SonerDikci, SeyhanTurkoz, YusufOzyalin, Fatma2024-08-042024-08-0420190271-36831460-2202https://doi.org/10.1080/02713683.2019.1578378https://hdl.handle.net/11616/98827Purpose: To evaluate the asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine (L-Arg) levels both in plasma and aqueous humor of primary open angle glaucoma (POAG) patients and matched controls.Patients and Methods: 25 primary open angle glaucoma patients and 42 control cases with senile cataract were included in the study. Plasma and aqueous humor ADMA, SDMA and L-Arg levels of the participants were measured by using liquid chromatography-tandem mass spectrometry.Results: A significant increase in aqueous humor SDMA level was detected in POAG patients compared with controls (p =0.0115). No significant difference was detected in plasma and aqueous humor ADMA, L-Arg levels.Conclusion: The aqueous humor levels of SDMA are found to be associated with POAG. The result of this current study supports the role of nitric oxide pathway in glaucoma.eninfo:eu-repo/semantics/closedAccessGlaucomaasymmetric dimethylargininesymmetric dimethylarginineL-arginineArticle4466196223070704810.1080/02713683.2019.15783782-s2.0-85067106560Q2WOS:000471943300007Q3