Uysal, MukreminSaglam, SezerBeypinar, IsmailSaglam, Esra KaytanMammadov, ElkhanOcak, BirolAybi, Ozge2026-04-042026-04-0420260735-79071532-4192https://doi.org/10.1080/07357907.2025.2595536https://hdl.handle.net/11616/109265The goal of this study was to look at the long-term survival outcomes and clinical characteristics of stage II/III locally advanced rectal cancer (LARC) patients who acquired pathological complete response (pCR) following neoadjuvant chemoradiotherapy (NCRT). The clinicopathological characteristics and treatment details of 277 LARC patients with pCR, relapse-free survival (RFS), overall survival (OS), and locoregional and systemic recurrence rates, were assessed. The 5-year RFS and OS rates were 85.6% and 90.9%. The rates of local and systemic recurrence were 3.6% and 7.9%. Our study confirmed the favorable results in survival in patients with LARC who achieved pCReninfo:eu-repo/semantics/closedAccessDisease-free survivalLocal recurrenceLocal advanced rectal cancerNeoadjuvant chemoradiationPathological complete responseOverall survivalSurgical outcomeArticle4421271354134763510.1080/07357907.2025.25955362-s2.0-105024909531Q3WOS:001631349200001Q3