Togal T.Gedik E.Ersoy M.O.2024-08-042024-08-0419991016-5150https://hdl.handle.net/11616/90847Volatile anaesthetics enhance the action of neuromuscular blockade to various degrees, the purpose of the present study is to compare the effects of volatile anaesthetics (isoflurane and sevoflurane) on the onset time of the neuromuscular blockade by vecuronium. Following approval from the ethic committee, 20 ASA I-II patients of either sex, aged 17-61 years old, were scheduled for elective laparoscopic surgery. Patients were randomly allocated to two groups. While induction of anaesthesia was performed with thiopentone 6 mg/kg and vecuronium 0.07 mg/kg, fentanyl 1 ?g/kg, lidocaine 1 mg/kg and maintained by 66/33 % N2O/O2 and sevoflurane (1.7 %) group I and isoflurane (1.2 %) in group II. The EMG response of the adductor pollicis was monitored by TOF-Guard stimulator (Biometer) at 20s intervals after train of four (TOF) stimulation of the ulnar nerve. Following intubation, whenever T1 returned to 25 % control additional doses of vecuronium was given (0.02 mg/kg). Supramaximal stimuli, duration 0.2 miliseconds and frequency 2 Hz were delivered at 20 seconds intervals to the ulnar nerve. The onset time (T1 max), duration of block (T1 25 %), time to maximal block after the second dose (T2 max), duration of action of maintenance doses (T2 25 %) and recovery times (T2 75 % - 25 %) were the parameters measured. There were no statistical significant differences between two volatile anaesthetics effects. In conclusion the effects of sevoflurane are similar to those of isoflurane on the neuromuscular block produced by vecuronium.trinfo:eu-repo/semantics/closedAccessIsofluraneSevofluraneVecuronium bromideArticle27148512-s2.0-0032934993N/A